Staging Bipolar Disorder

[Bipolar disorder: staging and neuroprogression].

In bipolar disorder illness progression has been associated with a higher number of mood episodes and hospitalizations, poorer response to treatment, and more severe cognitive and functional impairment. This supports the notion of the use of staging models in this illness. The value of staging models has long been recognized in many medical and malignant conditions. Staging models rely on the f...

Biomarkers and staging of bipolar disorder: a systematic review.

INTRODUCTION A growing body of evidence suggests that bipolar disorder (BD) is a progressive disease according to clinical, biochemical and neuroimaging findings. This study reviewed the literature on the relationship between specific biomarkers and BD stages. METHODS A comprehensive literature search of MEDLINE and PubMed was conducted to identify studies in English and Portuguese using the ...

Staging in bipolar disorder: one step closer to precision psychiatry.

Staging in bipolar disorder: one step closer to precision psychiatry Brisa S. Fernandes, Michael Berk IMPACT Strategic Research Centre and Barwon Health, School of Medicine, Deakin University, Geelong, VIC, Australia. Laboratório das Proteı́nas Ligantes do Cálcio no Sistema Nervoso Central, Departamento de Bioquı́mica, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, RS, Brazil. D...

Bipolar Disorder 3 Treatment of bipolar disorder

We review recent developments in the acute and long-term treatment of bipolar disorder and identify promising future routes to therapeutic innovation. Overall, advances in drug treatment remain quite modest. Antipsychotic drugs are effective in the acute treatment of mania; their efficacy in the treatment of depression is variable with the clearest evidence for quetiapine. Despite their widespr...

Bipolar Disorder